In vitro antimalarial activity of prenylated flavonoids from Erythrina fusca
Ethyl acetate (EtOAc) extract from the stem bark of Erythrina fusca showed a antimalarial activity against the multi-drug-resistant strain (K1) of Plasmodium falciparum , and six flavonoids, lupinifolin ( 1 ), citflavanone ( 2 ), erythrisenegalone ( 3 ), lonchocarpol A ( 4 ), liquiritigenin ( 5 ), a...
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| Veröffentlicht in: | Journal of natural medicines 2008-04, Vol.62 (2), p.217-220 |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Ethyl acetate (EtOAc) extract from the stem bark of
Erythrina fusca
showed a antimalarial activity against the multi-drug-resistant strain (K1) of
Plasmodium falciparum
, and six flavonoids, lupinifolin (
1
), citflavanone (
2
), erythrisenegalone (
3
), lonchocarpol A (
4
), liquiritigenin (
5
), and 8-prenyldaidzein (
6
), were isolated from the extract. Diprenylated flavanone
4
showed a notable antimalarial activity (IC
50
; 1.6 μg/mL); however
1
and
3
did not show the activity, even though these compounds possessed prenylated substitution. |
|---|---|
| ISSN: | 1340-3443 1861-0293 |
| DOI: | 10.1007/s11418-007-0214-z |