Synthesis of bis-diosgenin pyrazine dimers: New cephalostatin analogs

A convenient synthesis for bis-diosgenin pyrazine dimers, cephalostatin analogues is reported. These symmetrical dimeric steroid-pyrazines were obtained by the classical condensation of α-amino ketones, the most efficient method for pyrazine ring construction.

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Bibliographische Detailangaben
Veröffentlicht in:	Steroids 2008-07, Vol.73 (6), p.579-584
Hauptverfasser:	Shawakfeh, Khaled Q., Al-Said, Naim H., Al-Zoubi, Raed M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bis-diosgenin pyrazine dimers Cephalostatin analogs Dimerization Diosgenin - chemical synthesis Diosgenin - chemistry Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy Models, Molecular Molecular Structure Pyrazines - chemical synthesis Pyrazines - chemistry Spectrometry, Mass, Electrospray Ionization Synthesis Vertebrates: endocrinology
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Beschreibung
Zusammenfassung:	A convenient synthesis for bis-diosgenin pyrazine dimers, cephalostatin analogues is reported. These symmetrical dimeric steroid-pyrazines were obtained by the classical condensation of α-amino ketones, the most efficient method for pyrazine ring construction.
ISSN:	0039-128X 1878-5867
DOI:	10.1016/j.steroids.2008.01.012