Synthesis of Ketones from α-Oxocarboxylates and Aryl Bromides by Cu/Pd-Catalyzed Decarboxylative Cross-Coupling

The power of two metals: A Pd/Cu catalyst system mediates the in situ formation of acyl nucleophiles by decarboxylation of readily accessible and stable salts of α‐oxocarboxylic acids and their cross‐coupling with aryl or heteroaryl bromides to give ketones. The reaction may be used in the presence...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2008-04, Vol.47 (16), p.3043-3045
Hauptverfasser:	Gooßen, Lukas J, Rudolphi, Felix, Oppel, Christoph, Rodríguez, Nuria
Format:	Artikel
Sprache:	eng
Schlagworte:	aryl ketones Bromides Carboxylic Acids Catalysis Copper cross-coupling Cross-Linking Reagents Decarboxylation homogeneous catalysis Ketones - chemical synthesis Palladium
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creator	Gooßen, Lukas J Rudolphi, Felix Oppel, Christoph Rodríguez, Nuria
description	The power of two metals: A Pd/Cu catalyst system mediates the in situ formation of acyl nucleophiles by decarboxylation of readily accessible and stable salts of α‐oxocarboxylic acids and their cross‐coupling with aryl or heteroaryl bromides to give ketones. The reaction may be used in the presence of many functional groups and provides good yields.
doi_str_mv	10.1002/anie.200705127
format	Article
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subjects	aryl ketones Bromides Carboxylic Acids Catalysis Copper cross-coupling Cross-Linking Reagents Decarboxylation homogeneous catalysis Ketones - chemical synthesis Palladium
title	Synthesis of Ketones from α-Oxocarboxylates and Aryl Bromides by Cu/Pd-Catalyzed Decarboxylative Cross-Coupling
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