Synthesis of Ketones from α-Oxocarboxylates and Aryl Bromides by Cu/Pd-Catalyzed Decarboxylative Cross-Coupling

The power of two metals: A Pd/Cu catalyst system mediates the in situ formation of acyl nucleophiles by decarboxylation of readily accessible and stable salts of α‐oxocarboxylic acids and their cross‐coupling with aryl or heteroaryl bromides to give ketones. The reaction may be used in the presence of many functional groups and provides good yields.