Synthesis of Rhazinicine by a Metal-Catalyzed CH Bond Functionalization Strategy

Synthesis of Rhazinicine by a Metal-Catalyzed CH Bond Functionalization Strategy

Iterative and regioselective metal‐catalyzed CH bond functionalization has been utilized to develop a strategy for the first total synthesis of the pyrrole alkaloid rhazinicine (see scheme).

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Veröffentlicht in:Angewandte Chemie International Edition 2008-04, Vol.47 (16), p.3004-3007
Hauptverfasser: Beck, Elizabeth M., Hatley, Richard, Gaunt, Matthew J.
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids - chemical synthesis
Catalysis
Cyclization
CH activation
Heterocyclic Compounds, 4 or More Rings - chemical synthesis
Indolizines - chemical synthesis
Metals
natural products
Palladium
Pyrroles - chemical synthesis
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Beschreibung
Zusammenfassung:Iterative and regioselective metal‐catalyzed CH bond functionalization has been utilized to develop a strategy for the first total synthesis of the pyrrole alkaloid rhazinicine (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200705005