Synthesis of mono- and 1,3-disubstituted allenes from propargylic amines via palladium-catalysed hydride-transfer reaction

Synthesis of mono- and 1,3-disubstituted allenes from propargylic amines via palladium-catalysed hydride-transfer reaction

Mono- and 1,3-disubstituted allenes were synthesized from the corresponding propargylamines via palladium-catalysed hydride-transfer reaction. In the current transformation, propargylic amines can be handled as allenyl anion equivalents and introduced into various electrophiles to be transformed int...

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Veröffentlicht in:Organic & biomolecular chemistry 2008-01, Vol.6 (8), p.1471-1477
Hauptverfasser: Nakamura, Hiroyuki, Ishikura, Makoto, Sugiishi, Tsuyuka, Kamakura, Takaya, Biellmann, Jean-François
Format: Artikel
Sprache:eng
Schlagworte:
Alkadienes - chemical synthesis
Alkadienes - chemistry
Alkynes - chemistry
Amines - chemistry
Catalysis
Hydrogen - chemistry
Ligands
Molecular Structure
Palladium - chemistry
Stereoisomerism
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Zusammenfassung:Mono- and 1,3-disubstituted allenes were synthesized from the corresponding propargylamines via palladium-catalysed hydride-transfer reaction. In the current transformation, propargylic amines can be handled as allenyl anion equivalents and introduced into various electrophiles to be transformed into allenes under palladium-catalyzed conditions.
ISSN:1477-0520
1477-0539
DOI:10.1039/b718298h