Synthesis and study of antiviral and anti-radical properties of aminophenol derivatives
It has been shown that N-acyl and N-aryl derivatives of 4,4-di- tert-butyl-2-aminophenol passes the most marked antiviral activity. A number of sterically-hindered o-aminophenol derivatives have been synthesized, and their antiviral activity in parallel with reactivity towards commonly encountered f...
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Veröffentlicht in: | Bioorganic & medicinal chemistry 2008-04, Vol.18 (7), p.2420-2423 |
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Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | It has been shown that
N-acyl and
N-aryl derivatives of 4,4-di-
tert-butyl-2-aminophenol passes the most marked antiviral activity.
A number of sterically-hindered
o-aminophenol derivatives have been synthesized, and their antiviral activity in parallel with reactivity towards commonly encountered free-radical intermediates was investigated. Of the compounds tested, the highest activity in suppressing replication
of Herpes simplex type l viruses was displayed by
N-acyl and
N-aryl derivatives of 4,6-di-
tert-butyl-2-aminophenol, which were able to interact with organic free radicals and, at the same time, manifested low reactivity towards reactive oxygen species. |
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ISSN: | 0960-894X 0968-0896 1464-3405 1464-3391 |
DOI: | 10.1016/j.bmcl.2008.02.055 |