Synthesis and study of antiviral and anti-radical properties of aminophenol derivatives

It has been shown that N-acyl and N-aryl derivatives of 4,4-di- tert-butyl-2-aminophenol passes the most marked antiviral activity. A number of sterically-hindered o-aminophenol derivatives have been synthesized, and their antiviral activity in parallel with reactivity towards commonly encountered f...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2008-04, Vol.18 (7), p.2420-2423
Hauptverfasser: Shadyro, O., Ksendzova, G., Polozov, G., Sorokin, V., Boreko, E., Savinova, O., Dubovik, B., Bizunok, N.
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Sprache:eng
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Zusammenfassung:It has been shown that N-acyl and N-aryl derivatives of 4,4-di- tert-butyl-2-aminophenol passes the most marked antiviral activity. A number of sterically-hindered o-aminophenol derivatives have been synthesized, and their antiviral activity in parallel with reactivity towards commonly encountered free-radical intermediates was investigated. Of the compounds tested, the highest activity in suppressing replication of Herpes simplex type l viruses was displayed by N-acyl and N-aryl derivatives of 4,6-di- tert-butyl-2-aminophenol, which were able to interact with organic free radicals and, at the same time, manifested low reactivity towards reactive oxygen species.
ISSN:0960-894X
0968-0896
1464-3405
1464-3391
DOI:10.1016/j.bmcl.2008.02.055