Effect of Cytochrome P450 Polymorphisms on Platelet Reactivity After Treatment With Clopidogrel in Acute Coronary Syndrome

Genetic polymorphisms of cytochrome P450 (CYP) isoforms may promote variability in platelet response to clopidogrel. This study was conducted to analyze, in 603 patients with non–ST elevation acute coronary syndromes, the effect of CYP3A4, CYP3A5, and CYP2C19 gene polymorphisms on clopidogrel respon...

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Veröffentlicht in:	The American journal of cardiology 2008-04, Vol.101 (8), p.1088-1093
Hauptverfasser:	Frere, Corinne, MD, PhD, Cuisset, Thomas, MD, Morange, Pierre-Emmanuel, MD, PhD, Quilici, Jacques, MD, Camoin-Jau, Laurence, MD, PhD, Saut, Noémie, PhD, Faille, Dorothee, PhD, Lambert, Marc, MD, Juhan-Vague, Irène, MD, PhD, Bonnet, Jean-Louis, MD, Alessi, Marie-Christine, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Coronary Syndrome - drug therapy Acute coronary syndromes Adenosine Diphosphate Alleles Biological and medical sciences Body Mass Index Cardiology Cardiology. Vascular system Cardiovascular Cell Adhesion Molecules - metabolism Coronary heart disease Cytochrome P-450 Enzyme System - genetics Drug Resistance - genetics Female Gene expression Heart Heterozygote Humans Male Medical sciences Microfilament Proteins - metabolism Middle Aged Multivariate analysis Myocarditis. Cardiomyopathies P-Selectin - metabolism Pharmaceuticals Phosphoproteins - metabolism Phosphorylation Platelet Activation - genetics Platelet Aggregation Inhibitors - therapeutic use Polymorphism Polymorphism, Single Nucleotide Prospective Studies Proteins Studies Ticlopidine - analogs & derivatives Ticlopidine - therapeutic use
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Zusammenfassung:	Genetic polymorphisms of cytochrome P450 (CYP) isoforms may promote variability in platelet response to clopidogrel. This study was conducted to analyze, in 603 patients with non–ST elevation acute coronary syndromes, the effect of CYP3A4, CYP3A5, and CYP2C19 gene polymorphisms on clopidogrel response and post-treatment platelet reactivity assessed by adenosine diphosphate (ADP)–induced platelet aggregation, vasodilator-stimulated phosphoprotein phosphorylation index, and ADP-induced P-selectin expression. The CYP2C19*2 polymorphism was significantly associated with ADP-induced platelet aggregation, vasodilator-stimulated phosphoprotein phosphorylation index, and ADP-induced P-selectin expression in recessive (p
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2007.11.065