First Example of Direct RuO4-Catalyzed Oxidation of Isoxazolidines to 3-Isoxazolidones

RuO2/NaIO4 oxidation of 3-unsubstituted isoxazolidines, under ethyl acetate/water biphasic conditions, affords 3-isoxazolidones in good yields. The methodology can be used on both racemic and optically active isoxazolidines.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2007-05, Vol.72 (10), p.3958-3960
Hauptverfasser:	Piperno, Anna, Chiacchio, Ugo, Iannazzo, Daniela, Giofrè, Salvatore V, Romeo, Giovanni, Romeo, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Catalysis Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Isoxazoles - chemical synthesis Isoxazoles - chemistry Molecular Structure Organic chemistry Oxidation-Reduction Preparations and properties Ruthenium Compounds - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	RuO2/NaIO4 oxidation of 3-unsubstituted isoxazolidines, under ethyl acetate/water biphasic conditions, affords 3-isoxazolidones in good yields. The methodology can be used on both racemic and optically active isoxazolidines.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo070211n