A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus

The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP ( brain excitatory peptide), induces a substantial increase in the synaptic excitabil...

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Veröffentlicht in:Experimental neurology 2008-04, Vol.210 (2), p.793-796
Hauptverfasser: Immonen, Tiina, Alakuijala, Anniina, Hytönen, Marjo, Sainio, Kirsi, Poteryaev, Dmitry, Saarma, Mart, Pasternack, Michael, Sariola, Hannu
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Sprache:eng
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Zusammenfassung:The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP ( brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor.
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2007.12.018