A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus
The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP ( brain excitatory peptide), induces a substantial increase in the synaptic excitabil...
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Veröffentlicht in: | Experimental neurology 2008-04, Vol.210 (2), p.793-796 |
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Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (
brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to
N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor. |
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ISSN: | 0014-4886 1090-2430 |
DOI: | 10.1016/j.expneurol.2007.12.018 |