Effects of caffeine on the freezing of gait in Parkinson's disease

Caffeine is a nonselective competitive blockade of adenosine A1 and A2A receptors. In this report, we studied the efficacy of 100 mg of caffeine per day on the freezing of gait (FOG) for patients with Parkinson's disease. Different subtypes of FOG showed different therapeutic responses to caffe...

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Veröffentlicht in:	Movement disorders 2007-04, Vol.22 (5), p.710-712
Hauptverfasser:	Kitagawa, Mayumi, Houzen, Hideki, Tashiro, Kunio
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine Adenosine A1 Receptor Antagonists Adenosine A2 Receptor Antagonists Aged Aged, 80 and over Biological and medical sciences caffeine Caffeine - therapeutic use Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drug Tolerance Female Follow-Up Studies freezing of gait Gait Disorders, Neurologic - drug therapy Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy heel-off Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurologic Examination - drug effects Neurology Parkinson Disease - drug therapy Parkinson's disease
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Zusammenfassung:	Caffeine is a nonselective competitive blockade of adenosine A1 and A2A receptors. In this report, we studied the efficacy of 100 mg of caffeine per day on the freezing of gait (FOG) for patients with Parkinson's disease. Different subtypes of FOG showed different therapeutic responses to caffeine. Caffeine improved “total akinesia” type of FOG, but had no effect on “trembling in place.” Tolerance developed to the beneficial effect of caffeine on FOG within a few months, but a 2‐week caffeine withdrawal period could restore the effect of caffeine. © 2007 Movement Disorder Society
ISSN:	0885-3185 1531-8257
DOI:	10.1002/mds.21208