Tumor-specificity and Type of Cell Death Induced by Vitamin K2 Derivatives and Prenylalcohols

Fourteen vitamin K 2 (menaquinone (MK)-n, n=1~14) and ten prenylalcohol derivatives (n=1~10) with different numbers (n) of isoprenyl groups in the side chains were investigated for their cytotoxicity against nine human tumor cell lines and three human normal oral cells. Among the vitamin K 2 derivat...

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Veröffentlicht in:	Anticancer research 2008-01, Vol.28 (1A), p.151-158
Hauptverfasser:	SAKAGAMI, Hiroshi, HASHIMOTO, Ken, SUZUKI, Fumika, ISHIHARA, Mariko, KIKUCHI, Hirotaka, KATAYAMA, Tadashi, SATOH, Kazue
Format:	Artikel
Sprache:	eng
Schlagworte:	Biogenic Polyamines - metabolism Biological and medical sciences Cell Death - drug effects Cell Line, Tumor Drug Screening Assays, Antitumor HL-60 Cells Humans K562 Cells Medical sciences Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Pentanols - pharmacology Tumors Vitamin K 2 - analogs & derivatives Vitamin K 2 - pharmacology Vitamins - pharmacology
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Zusammenfassung:	Fourteen vitamin K 2 (menaquinone (MK)-n, n=1~14) and ten prenylalcohol derivatives (n=1~10) with different numbers (n) of isoprenyl groups in the side chains were investigated for their cytotoxicity against nine human tumor cell lines and three human normal oral cells. Among the vitamin K 2 derivatives, MK-2 (n=2) showed the greatest cytotoxicity, followed by MK-1 (n=1) and MK-3 (n=3). MK-1, MK-2 and MK-3 showed the highest tumor-specific index (TS= >2.0, 2.0 and >1.7, respectively). Among the prenylalcohols, geranylgeraniol (GG) (n=4) showed the highest cytotoxicity, followed by farnesol (n=3) and geranylfarnesol (GF) (n=3). GG showed the highest tumor-specificity (TS=1.8), followed by farnesol (TS=>1.4), GF (TS=>
ISSN:	0250-7005 1791-7530