Preparation of Quinoline Hexose Analogs as Novel Chloroquine-Resistant Malaria Treatments (1). Synthesis of 4-Hydroxyquinoline-β-glucosides

Quinoline hexose analogs are expected to be useful as novel agents for treatment of chloroquine-resistant malaria. Here, we report preparation of 4-hydroxy quinoline-β-glucosides from anilines in 4 steps.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 2007, Vol.55(5), pp.821-824
Hauptverfasser:	Suzuki, Hiroshi, Aly, Nagwa S. M., Wataya, Yusuke, Kim, Hye-Sook, Tamai, Ikumi, Kita, Masaki, Uemura, Daisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - pharmacology Chloroquine - pharmacology chloroquine-resistant malaria treatment Drug Resistance Glucosides - chemical synthesis Glucosides - pharmacology Hexoses - chemical synthesis Hexoses - pharmacology Hydrolysis Hydroxyquinolines - chemical synthesis Hydroxyquinolines - pharmacology Magnetic Resonance Spectroscopy malaria Plasmodium falciparum - drug effects quinoline-glucosides Quinolones - chemical synthesis Quinolones - pharmacology Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Infrared
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Beschreibung
Zusammenfassung:	Quinoline hexose analogs are expected to be useful as novel agents for treatment of chloroquine-resistant malaria. Here, we report preparation of 4-hydroxy quinoline-β-glucosides from anilines in 4 steps.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.55.821