Age-related macular degeneration and mortality from cardiovascular disease or stroke
Background/aims:Age-related macular degeneration (AMD) and vascular disease share similar risk factors. Recent data suggest AMD may independently predict stroke or coronary heart disease. We prospectively assessed the relationship between AMD and risk of stroke- or cardiovascular-related death in an...
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| Veröffentlicht in: | British journal of ophthalmology 2008-04, Vol.92 (4), p.509-512 |
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| creator | Tan, J S L Wang, J J Liew, G Rochtchina, E Mitchell, P |
| description | Background/aims:Age-related macular degeneration (AMD) and vascular disease share similar risk factors. Recent data suggest AMD may independently predict stroke or coronary heart disease. We prospectively assessed the relationship between AMD and risk of stroke- or cardiovascular-related death in an Australian population.Methods:Of 3654 baseline participants (1992–4) aged 49+ years, 2335 were re-examined after 5 years and 1952 after 10 years. Retinal photographs were graded using the Wisconsin System. History and physical examination provided data on possible risk factors. Deaths and cause of death were confirmed by data linkage with the Australian National Death Index. Risk ratios (RR) were estimated in Cox models.Results:Among persons aged |
| doi_str_mv | 10.1136/bjo.2007.131706 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70445510</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4012469841</sourcerecordid><originalsourceid>FETCH-LOGICAL-b426t-c99720b98f0660980c5de547409fd7faac9e88f47c337ad67fdc5d11828287733</originalsourceid><addsrcrecordid>eNqFkEtr3DAURkVoSabTrrsrhpIsCp7oYUvWMkxehdBu0i66EdfyVfDEtlLJDsm_rwabFLIJEgjxHX1cHUI-M7phTMjTeuc3nFK1YYIpKg_IihWyyjlV-h1Z0ZTkjEl2RD7EuEtXLpk6JEesEoymvSK3Z3eYB-xgxCbrwU4dhKzBOxwwwNj6IYMhBT6M0LXjc-aC7zMLoWn9I8QFbyNCxMyHLI7B3-NH8t5BF_HTcq7Jr8uL2-11fvPz6vv27CavCy7H3GqtOK115aiUVFfUlg2WhSqodo1yAFZjVblCWSEUNFK5JhGMVTwtpYRYk5O59yH4vxPG0fRttNh1MKCfolG0KMoy_XRNvr4Cd34KQ5rNMKUqzbWW-7rTmbLBxxjQmYfQ9hCeDaNmr9sk3Wav28y604svS-9U99j85xe_CThegCQLOhdgsG184ThNbVzsi_KZa-OITy85hHsjlVCl-fF7a66kOOeXhTR_Ev9t5ut-9-aU_wDv2qMZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1778929963</pqid></control><display><type>article</type><title>Age-related macular degeneration and mortality from cardiovascular disease or stroke</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Tan, J S L ; Wang, J J ; Liew, G ; Rochtchina, E ; Mitchell, P</creator><creatorcontrib>Tan, J S L ; Wang, J J ; Liew, G ; Rochtchina, E ; Mitchell, P</creatorcontrib><description>Background/aims:Age-related macular degeneration (AMD) and vascular disease share similar risk factors. Recent data suggest AMD may independently predict stroke or coronary heart disease. We prospectively assessed the relationship between AMD and risk of stroke- or cardiovascular-related death in an Australian population.Methods:Of 3654 baseline participants (1992–4) aged 49+ years, 2335 were re-examined after 5 years and 1952 after 10 years. Retinal photographs were graded using the Wisconsin System. History and physical examination provided data on possible risk factors. Deaths and cause of death were confirmed by data linkage with the Australian National Death Index. Risk ratios (RR) were estimated in Cox models.Results:Among persons aged <75 years at baseline, early AMD predicted a doubling of cardiovascular mortality (RR, 2.32; 95% confidence interval (CI), 1.03 to 5.19), over the next decade, after controlling for traditional cardiovascular risk factors. Late AMD predicted fivefold higher cardiovascular mortality (RR, 5.57; 95% CI, 1.35 to 22.99) and 10-fold higher stroke mortality (RR, 10.21; 95% CI, 2.39 to 43.60) after adjusting for age and sex only. These associations were not present when persons older than 75 were included.Conclusion:AMD predicted stroke and cardiovascular events over the long term in persons aged 49–75 years. This may have potential implications for new intravitreal anti-VEGF AMD therapies.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.2007.131706</identifier><identifier>PMID: 18310310</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Age Factors ; Aged ; Australia - epidemiology ; Biological and medical sciences ; Cardiovascular disease ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - mortality ; Epidemiologic Methods ; Female ; Health risk assessment ; Heart attacks ; Humans ; Macular degeneration ; Macular Degeneration - complications ; Macular Degeneration - mortality ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Mortality ; Neurology ; Ophthalmology ; Prognosis ; Retinopathies ; Stroke - complications ; Stroke - mortality ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>British journal of ophthalmology, 2008-04, Vol.92 (4), p.509-512</ispartof><rights>2008 BMJ Publishing Group Ltd</rights><rights>2008 INIST-CNRS</rights><rights>Copyright: 2008 2008 BMJ Publishing Group Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b426t-c99720b98f0660980c5de547409fd7faac9e88f47c337ad67fdc5d11828287733</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bjo.bmj.com/content/92/4/509.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://bjo.bmj.com/content/92/4/509.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3182,23551,27903,27904,77347,77378</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20200236$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18310310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, J S L</creatorcontrib><creatorcontrib>Wang, J J</creatorcontrib><creatorcontrib>Liew, G</creatorcontrib><creatorcontrib>Rochtchina, E</creatorcontrib><creatorcontrib>Mitchell, P</creatorcontrib><title>Age-related macular degeneration and mortality from cardiovascular disease or stroke</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Background/aims:Age-related macular degeneration (AMD) and vascular disease share similar risk factors. Recent data suggest AMD may independently predict stroke or coronary heart disease. We prospectively assessed the relationship between AMD and risk of stroke- or cardiovascular-related death in an Australian population.Methods:Of 3654 baseline participants (1992–4) aged 49+ years, 2335 were re-examined after 5 years and 1952 after 10 years. Retinal photographs were graded using the Wisconsin System. History and physical examination provided data on possible risk factors. Deaths and cause of death were confirmed by data linkage with the Australian National Death Index. Risk ratios (RR) were estimated in Cox models.Results:Among persons aged <75 years at baseline, early AMD predicted a doubling of cardiovascular mortality (RR, 2.32; 95% confidence interval (CI), 1.03 to 5.19), over the next decade, after controlling for traditional cardiovascular risk factors. Late AMD predicted fivefold higher cardiovascular mortality (RR, 5.57; 95% CI, 1.35 to 22.99) and 10-fold higher stroke mortality (RR, 10.21; 95% CI, 2.39 to 43.60) after adjusting for age and sex only. These associations were not present when persons older than 75 were included.Conclusion:AMD predicted stroke and cardiovascular events over the long term in persons aged 49–75 years. This may have potential implications for new intravitreal anti-VEGF AMD therapies.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Australia - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Macular degeneration</subject><subject>Macular Degeneration - complications</subject><subject>Macular Degeneration - mortality</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mortality</subject><subject>Neurology</subject><subject>Ophthalmology</subject><subject>Prognosis</subject><subject>Retinopathies</subject><subject>Stroke - complications</subject><subject>Stroke - mortality</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkEtr3DAURkVoSabTrrsrhpIsCp7oYUvWMkxehdBu0i66EdfyVfDEtlLJDsm_rwabFLIJEgjxHX1cHUI-M7phTMjTeuc3nFK1YYIpKg_IihWyyjlV-h1Z0ZTkjEl2RD7EuEtXLpk6JEesEoymvSK3Z3eYB-xgxCbrwU4dhKzBOxwwwNj6IYMhBT6M0LXjc-aC7zMLoWn9I8QFbyNCxMyHLI7B3-NH8t5BF_HTcq7Jr8uL2-11fvPz6vv27CavCy7H3GqtOK115aiUVFfUlg2WhSqodo1yAFZjVblCWSEUNFK5JhGMVTwtpYRYk5O59yH4vxPG0fRttNh1MKCfolG0KMoy_XRNvr4Cd34KQ5rNMKUqzbWW-7rTmbLBxxjQmYfQ9hCeDaNmr9sk3Wav28y604svS-9U99j85xe_CThegCQLOhdgsG184ThNbVzsi_KZa-OITy85hHsjlVCl-fF7a66kOOeXhTR_Ev9t5ut-9-aU_wDv2qMZ</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Tan, J S L</creator><creator>Wang, J J</creator><creator>Liew, G</creator><creator>Rochtchina, E</creator><creator>Mitchell, P</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Age-related macular degeneration and mortality from cardiovascular disease or stroke</title><author>Tan, J S L ; Wang, J J ; Liew, G ; Rochtchina, E ; Mitchell, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b426t-c99720b98f0660980c5de547409fd7faac9e88f47c337ad67fdc5d11828287733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Australia - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - complications</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Macular degeneration</topic><topic>Macular Degeneration - complications</topic><topic>Macular Degeneration - mortality</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mortality</topic><topic>Neurology</topic><topic>Ophthalmology</topic><topic>Prognosis</topic><topic>Retinopathies</topic><topic>Stroke - complications</topic><topic>Stroke - mortality</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, J S L</creatorcontrib><creatorcontrib>Wang, J J</creatorcontrib><creatorcontrib>Liew, G</creatorcontrib><creatorcontrib>Rochtchina, E</creatorcontrib><creatorcontrib>Mitchell, P</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, J S L</au><au>Wang, J J</au><au>Liew, G</au><au>Rochtchina, E</au><au>Mitchell, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related macular degeneration and mortality from cardiovascular disease or stroke</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>92</volume><issue>4</issue><spage>509</spage><epage>512</epage><pages>509-512</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>Background/aims:Age-related macular degeneration (AMD) and vascular disease share similar risk factors. Recent data suggest AMD may independently predict stroke or coronary heart disease. We prospectively assessed the relationship between AMD and risk of stroke- or cardiovascular-related death in an Australian population.Methods:Of 3654 baseline participants (1992–4) aged 49+ years, 2335 were re-examined after 5 years and 1952 after 10 years. Retinal photographs were graded using the Wisconsin System. History and physical examination provided data on possible risk factors. Deaths and cause of death were confirmed by data linkage with the Australian National Death Index. Risk ratios (RR) were estimated in Cox models.Results:Among persons aged <75 years at baseline, early AMD predicted a doubling of cardiovascular mortality (RR, 2.32; 95% confidence interval (CI), 1.03 to 5.19), over the next decade, after controlling for traditional cardiovascular risk factors. Late AMD predicted fivefold higher cardiovascular mortality (RR, 5.57; 95% CI, 1.35 to 22.99) and 10-fold higher stroke mortality (RR, 10.21; 95% CI, 2.39 to 43.60) after adjusting for age and sex only. These associations were not present when persons older than 75 were included.Conclusion:AMD predicted stroke and cardiovascular events over the long term in persons aged 49–75 years. This may have potential implications for new intravitreal anti-VEGF AMD therapies.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>18310310</pmid><doi>10.1136/bjo.2007.131706</doi><tpages>4</tpages></addata></record> |
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| subjects | Age Factors Aged Australia - epidemiology Biological and medical sciences Cardiovascular disease Cardiovascular Diseases - complications Cardiovascular Diseases - mortality Epidemiologic Methods Female Health risk assessment Heart attacks Humans Macular degeneration Macular Degeneration - complications Macular Degeneration - mortality Male Medical sciences Middle Aged Miscellaneous Mortality Neurology Ophthalmology Prognosis Retinopathies Stroke - complications Stroke - mortality Vascular diseases and vascular malformations of the nervous system |
| title | Age-related macular degeneration and mortality from cardiovascular disease or stroke |
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