Clinical impact of MRSA in a stem cell transplant unit: analysis before, during and after an MRSA outbreak

Meticillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen, with an increased incidence in the UK since 1993, causing serious morbidity and mortality in immunosuppressed patients. We analysed the frequency and outcome of MRSA infection in a single-centre transplant population o...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2007-05, Vol.39 (10), p.623-629
Hauptverfasser:	SHAW, B. E, BOSWELL, T, BYRNE, J. L, YATES, C, RUSSELL, N. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Autografts Bacteremia Bacteremia - epidemiology Bacteremia - etiology Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Control Disease Outbreaks - prevention & control Drug resistance Eradication Female Frequency analysis Health aspects Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Humans Infections Influence Male Medical sciences Methicillin Methicillin Resistance Methods Middle Aged Morbidity Neutropenia Nosocomial infection Outbreaks Pathogens Patients Public health Retrospective Studies Risk factors Staphylococcal Infections - epidemiology Staphylococcal Infections - etiology Staphylococcal Infections - prevention & control Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - pathogenicity Staphylococcus aureus infections Staphylococcus infections Stem cell transplantation Stem cells Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation, Autologous Transplantation, Homologous Transplants Transplants & implants United Kingdom - epidemiology
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Zusammenfassung:	Meticillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen, with an increased incidence in the UK since 1993, causing serious morbidity and mortality in immunosuppressed patients. We analysed the frequency and outcome of MRSA infection in a single-centre transplant population over a 5-year period. The total number of patients infected was 41/776 (5%). The frequency in autologous, sibling and unrelated donor transplants was 3, 6 and 9%, respectively. Prior to 2004, the incidence was
ISSN:	0268-3369 1476-5365
DOI:	10.1038/sj.bmt.1705654