A new advanced glycation inhibitor, LR-90, prevents experimental diabetic retinopathy in rats

Background:Diabetic retinopathy is associated with accumulation of advanced glycation end products in the retinal microvasculature. LR-90 is an effective multistage inhibitor of advanced glycation with renoprotective and anti-inflammatory properties.Aim:To explore the role of LR-90 in the progressio...

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Veröffentlicht in:	British journal of ophthalmology 2008-04, Vol.92 (4), p.545-547
Hauptverfasser:	Bhatwadekar, A, Glenn, J V, Figarola, J L, Scott, S, Gardiner, T A, Rahbar, S, Stitt, A W
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Biological and medical sciences Body Weight - drug effects Butyrates - therapeutic use Cholesterol Cholesterol - blood Creatinine - urine Diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - pathology Diabetes. Impaired glucose tolerance Diabetic retinopathy Diabetic Retinopathy - pathology Diabetic Retinopathy - prevention & control Disease Progression Drug Evaluation, Preclinical - methods Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glycation End Products, Advanced - antagonists & inhibitors Laboratory animals Male Medical sciences Miscellaneous Ophthalmology Prevention Rats Rats, Sprague-Dawley Retinopathies Rodents Studies Triglycerides - blood Variance analysis
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Zusammenfassung:	Background:Diabetic retinopathy is associated with accumulation of advanced glycation end products in the retinal microvasculature. LR-90 is an effective multistage inhibitor of advanced glycation with renoprotective and anti-inflammatory properties.Aim:To explore the role of LR-90 in the progression of experimental diabetic retinopathy.Methods:Streptozotocin-induced diabetic Sprague–Dawley rats were treated with LR-90 (50 mg/l in drinking water) for up to 32 weeks. At the end of the study, eyes were enucleated and subjected to trypsin digestion and staining with light green/haematoxylin. Acellular capillaries and pericytes were quantified in random fields using light microscopy.Results:In the LR-90-treated diabetic animals, acellular capillary numbers were reduced to 1.63 (0.20) from 2.58 (0.49) (p
ISSN:	0007-1161 1468-2079
DOI:	10.1136/bjo.2007.127910