Why myc? An unexpected ingredient in the stem cell cocktail
Screening cocktails of candidate genes for induction of pluripotency and self-renewal in nonstem cells has identified a surprising new embryonic stem cell regulator, the myc proto-oncogene. Here the possible mechanisms by which myc controls self-renewal and pluripotency are discussed.
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| Veröffentlicht in: | Cell stem cell 2008-01, Vol.2 (1), p.18-21 |
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| container_title | Cell stem cell |
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| creator | Knoepfler, Paul S |
| description | Screening cocktails of candidate genes for induction of pluripotency and self-renewal in nonstem cells has identified a surprising new embryonic stem cell regulator, the myc proto-oncogene. Here the possible mechanisms by which myc controls self-renewal and pluripotency are discussed. |
| doi_str_mv | 10.1016/j.stem.2007.12.004 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Cell stem cell, 2008-01, Vol.2 (1), p.18-21 |
| issn | 1934-5909 1875-9777 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70444330 |
| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Differentiation Cell Lineage Embryo, Mammalian - metabolism Gene Expression Regulation, Developmental Humans Mice Mice, Knockout Models, Animal Octamer Transcription Factor-3 - metabolism Oligonucleotide Array Sequence Analysis Pluripotent Stem Cells - physiology Proto-Oncogene Proteins c-myc - physiology Regenerative Medicine Signal Transduction SOXB1 Transcription Factors - metabolism STAT3 Transcription Factor - metabolism Stem Cells - physiology |
| title | Why myc? An unexpected ingredient in the stem cell cocktail |
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