Why myc? An unexpected ingredient in the stem cell cocktail

Screening cocktails of candidate genes for induction of pluripotency and self-renewal in nonstem cells has identified a surprising new embryonic stem cell regulator, the myc proto-oncogene. Here the possible mechanisms by which myc controls self-renewal and pluripotency are discussed.

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Bibliographische Detailangaben
Veröffentlicht in:	Cell stem cell 2008-01, Vol.2 (1), p.18-21
1. Verfasser:	Knoepfler, Paul S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Differentiation Cell Lineage Embryo, Mammalian - metabolism Gene Expression Regulation, Developmental Humans Mice Mice, Knockout Models, Animal Octamer Transcription Factor-3 - metabolism Oligonucleotide Array Sequence Analysis Pluripotent Stem Cells - physiology Proto-Oncogene Proteins c-myc - physiology Regenerative Medicine Signal Transduction SOXB1 Transcription Factors - metabolism STAT3 Transcription Factor - metabolism Stem Cells - physiology
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Beschreibung
Zusammenfassung:	Screening cocktails of candidate genes for induction of pluripotency and self-renewal in nonstem cells has identified a surprising new embryonic stem cell regulator, the myc proto-oncogene. Here the possible mechanisms by which myc controls self-renewal and pluripotency are discussed.
ISSN:	1934-5909 1875-9777
DOI:	10.1016/j.stem.2007.12.004