Do cells let-7 determine stemness?

During oncogenic transformation, microRNA levels of the translation-regulatory factor let-7 correlate inversely with expression of the HMGA2 oncoprotein. In a recent issue of Cell, Yu et al. (2007) now provide evidence that the let-7/HMGA2 linkage could be a signature of cancer stem cells in vivo, w...

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Veröffentlicht in:	Cell stem cell 2008-01, Vol.2 (1), p.8-9
Hauptverfasser:	Dröge, Peter, Davey, Curt A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Transformation, Neoplastic - genetics Female Gene Expression Regulation, Neoplastic HMGA2 Protein - genetics HMGA2 Protein - metabolism Humans Mice MicroRNAs - genetics MicroRNAs - metabolism Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Polymorphism, Single Nucleotide
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Zusammenfassung:	During oncogenic transformation, microRNA levels of the translation-regulatory factor let-7 correlate inversely with expression of the HMGA2 oncoprotein. In a recent issue of Cell, Yu et al. (2007) now provide evidence that the let-7/HMGA2 linkage could be a signature of cancer stem cells in vivo, with broader implications for stem cell research.
ISSN:	1934-5909 1875-9777
DOI:	10.1016/j.stem.2007.12.003