Correlation of preoperative serum vascular endothelial growth factor level with CA125 level in patients with epithelial ovarian cancer and its prognostic value

To analyze the correlation of preoperative serum vascular endothelial growth factor (VEGF) level with serum CA125 level in patients with epithelial ovarian cancer (EOC), and to evaluate the prognostic value of preoperative serum VEGF in these patients. Forty-one patients with EOC were included as st...

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Veröffentlicht in:	Chung-hua fu chʿan kʿo tsa chih 2008-01, Vol.43 (1), p.9-12
Hauptverfasser:	Tan, Xian-jie, Lang, Jing-he, Shen, Keng, Wang, Lin, Wu, Ming, Xu, Xiu-ying
Format:	Artikel
Sprache:	chi
Schlagworte:	Adult Aged Biomarkers, Tumor - blood CA-125 Antigen - blood Enzyme-Linked Immunosorbent Assay Female Humans Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Ovarian Neoplasms - blood Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Predictive Value of Tests Prognosis Survival Analysis Vascular Endothelial Growth Factors - blood
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Zusammenfassung:	To analyze the correlation of preoperative serum vascular endothelial growth factor (VEGF) level with serum CA125 level in patients with epithelial ovarian cancer (EOC), and to evaluate the prognostic value of preoperative serum VEGF in these patients. Forty-one patients with EOC were included as study group, while 20 healthy women were selected as control group. Enzyme-linked immunosorbent assay (ELISA) and chemiluminescence assay were used to measure serum VEGF and CA125 level respectively. The correlations of serum VEGF with CA125 level, postoperative recurrence rate and survival time were analyzed retrospectively. Serum VEGF levels in patients with EOC were higher than those in healthy women, with the median of 415 and 165 ng/L, range 110-2120 and 100-735 ng/L respectively (P
ISSN:	0529-567X