The Influence of Mechanical Processing of Dry Powder Inhaler Carriers on Drug Aerosolization Performance

The Influence of Mechanical Processing of Dry Powder Inhaler Carriers on Drug Aerosolization Performance

The influence of processing on the performance of carrier material used in dry powder inhalers was investigated. α-Lactose monohydrate crystals were processed by ball milling for cumulative time durations and their properties evaluated. As expected, milling reduced the median particle diameter while...

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Veröffentlicht in:Journal of pharmaceutical sciences 2007-05, Vol.96 (5), p.1331-1341
Hauptverfasser: Young, Paul M., Chan, Hak-kim, Chiou, Herbert, Edge, Stephen, Tee, Terence H.S., Traini, Daniela
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Inhalation
aerosolization
Aerosols
amorphous
Anti-Asthmatic Agents - administration & dosage
Anti-Asthmatic Agents - chemistry
Biological and medical sciences
Chemistry, Pharmaceutical
Crystallization
Drug Carriers
dry powder
Excipients - chemistry
fines
General pharmacology
Humidity
inhalation
Lactose - chemistry
Medical sciences
Microscopy, Electron, Scanning
milling
Nebulizers and Vaporizers
Nedocromil - administration & dosage
Nedocromil - chemistry
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Powders
recrystallization
surface activation
Surface Properties
Technology, Pharmaceutical - methods
Time Factors
Water - chemistry
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Zusammenfassung:The influence of processing on the performance of carrier material used in dry powder inhalers was investigated. α-Lactose monohydrate crystals were processed by ball milling for cumulative time durations and their properties evaluated. As expected, milling reduced the median particle diameter while increasing fine particulate (
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.20933