Massarilactones E-G, new metabolites from the endophytic fungus Coniothyrium sp., associated with the plant Artimisia maritima

Three new massarilactones E‐G (1–3) and the massarilactone acetonide (4) were isolated from the ethyl acetate extract of the endophytic fungus Coniothyrium sp., associated with the plant Artimisia maritima. Their structures were determined by analysis of the 1D and 2D NMR and mass spectroscopic data...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 2007-06, Vol.19 (6), p.464-470
Hauptverfasser:	Krohn, Karsten, Zia-Ullah, Hussain, Hidayat, Flörke, Ulrich, Schulz, Barbara, Draeger, Siegfried, Pescitelli, Gennaro, Salvadori, Piero, Antus, Sándor, Kurtán, Tibor
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry, Pharmaceutical - methods Chromatography, Thin Layer Coniothyrium sp Diterpenes - chemistry Diterpenes - isolation & purification fungal metabolites Fungi - metabolism Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Magnetic Resonance Spectroscopy massarilactones Models, Chemical Molecular Structure Plants - microbiology solid-state CD-TDDFT method Spectrophotometry, Infrared Spectrophotometry, Ultraviolet structure elucidation X-ray analysis X-Ray Diffraction
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Zusammenfassung:	Three new massarilactones E‐G (1–3) and the massarilactone acetonide (4) were isolated from the ethyl acetate extract of the endophytic fungus Coniothyrium sp., associated with the plant Artimisia maritima. Their structures were determined by analysis of the 1D and 2D NMR and mass spectroscopic data. The structure of massarilactones E (1) was confirmed by X‐ray diffraction analysis, and its absolute configuration determined by the solid‐state CD/TDDFT method. Chirality, 2007. © 2007 Wiley‐Liss, Inc.
ISSN:	0899-0042 1520-636X
DOI:	10.1002/chir.20402