Are hematopoietic stem cells generated in the placenta?

In this issue of Cell Stem Cell, the origin of multipotent hematopoietic cells present in the placenta has been assessed in Ncx1(-/-) embryos lacking a functional heart and circulation. Rhodes and colleagues (Rhodes et al., 2008) found lymphoid progenitors in the placenta, as well as in dorsal aorta...

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Veröffentlicht in:	Cell Stem Cell 2008-03, Vol.2 (3), p.197-198
Hauptverfasser:	Kieusseian, Aurelie, Cumano, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Lineage Cell Lineage - physiology Core Binding Factor Alpha 2 Subunit Core Binding Factor Alpha 2 Subunit - genetics Core Binding Factor Alpha 2 Subunit - metabolism Female Hematopoiesis, Extramedullary Hematopoiesis, Extramedullary - physiology Hematopoietic Stem Cells Hematopoietic Stem Cells - physiology Immunology Life Sciences Liver Liver - cytology Liver - embryology Mice Mice, Knockout Placenta Placenta - blood supply Placenta - cytology Platelet Membrane Glycoprotein IIb Platelet Membrane Glycoprotein IIb - genetics Platelet Membrane Glycoprotein IIb - metabolism Pregnancy Pregnancy - physiology Sodium-Calcium Exchanger Sodium-Calcium Exchanger - genetics Sodium-Calcium Exchanger - metabolism
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Beschreibung
Zusammenfassung:	In this issue of Cell Stem Cell, the origin of multipotent hematopoietic cells present in the placenta has been assessed in Ncx1(-/-) embryos lacking a functional heart and circulation. Rhodes and colleagues (Rhodes et al., 2008) found lymphoid progenitors in the placenta, as well as in dorsal aorta and yolk sac and vitelline vessels, indicating that they arose in situ.
ISSN:	1934-5909 1875-9777
DOI:	10.1016/j.stem.2008.02.013