Ciliatamides A−C, Bioactive Lipopeptides from the Deep-Sea Sponge Aaptos ciliata

Three lipopeptides, ciliatamides A−C (1–3), were isolated from the deep-sea sponge Aaptos ciliata, and their structures were elucidated on the basis of spectroscopic and chemical methods. Ciliatamides A (1) and B (2) were found to be antileishmanial, while 2 also exhibited marginal cytotoxicity to H...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2008-03, Vol.71 (3), p.469-472
Hauptverfasser:	Nakao, Yoichi, Kawatsu, Shizuka, Okamoto, Chikane, Okamoto, Masaaki, Matsumoto, Yoshitsugu, Matsunaga, Shigeki, van Soest, Rob. W. M, Fusetani, Nobuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Antiprotozoal Agents - chemistry Antiprotozoal Agents - isolation & purification Antiprotozoal Agents - pharmacology Biological and medical sciences Drug Screening Assays, Antitumor General pharmacology HeLa Cells Humans Leishmania - drug effects Lipopeptides Lipoproteins - chemistry Lipoproteins - isolation & purification Lipoproteins - pharmacology Medical sciences Molecular Structure Oceans and Seas Oligopeptides - chemistry Oligopeptides - isolation & purification Oligopeptides - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry
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Zusammenfassung:	Three lipopeptides, ciliatamides A−C (1–3), were isolated from the deep-sea sponge Aaptos ciliata, and their structures were elucidated on the basis of spectroscopic and chemical methods. Ciliatamides A (1) and B (2) were found to be antileishmanial, while 2 also exhibited marginal cytotoxicity to HeLa cells.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np8000317