Urukthapelstatin A, a Novel Cytotoxic Substance from Marine-derived Mechercharimyces asporophorigenens YM11-542: II. Physico-chemical Properties and Structural Elucidation

The new cyclic peptide antibiotic, urukthapelstatin A, has been isolated from a culture of Thermoactinomycetaceae bacterium Mechercharimyces asporophorigenens YM11-542. The structure of urukthapelstatin A was elucidated by NMR, MS, Marfey analysis, chiral HPLC and X-ray crystal analyses.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 2007-04, Vol.60 (4), p.256-260
Hauptverfasser:	Matsuo, Yoshihide, Kanoh, Kaneo, Imagawa, Hiroshi, Adachi, Kyoko, Nishizawa, Mugio, Shizuri, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemistry Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Crystallography, X-Ray Gram-Positive Endospore-Forming Bacteria - metabolism Leucine - analogs & derivatives Leucine - chemistry Life Sciences Magnetic Resonance Spectroscopy Marine Mechercharimyces asporophorigenens Medicinal Chemistry Microbiology Organic Chemistry original-article Thermoactinomycetaceae Thiazoles - chemistry Water Microbiology
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Beschreibung
Zusammenfassung:	The new cyclic peptide antibiotic, urukthapelstatin A, has been isolated from a culture of Thermoactinomycetaceae bacterium Mechercharimyces asporophorigenens YM11-542. The structure of urukthapelstatin A was elucidated by NMR, MS, Marfey analysis, chiral HPLC and X-ray crystal analyses.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2007.31