C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction : Leicester acute myocardial infarction peptide (LAMP) study

The role of the vasopressin system after acute myocardial infarction is unclear. Copeptin, the C-terminal part of the vasopressin prohormone, is secreted stoichiometrically with vasopressin. We compared the prognostic value of copeptin and an established marker, N-terminal pro-B-type natriuretic pep...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2007-04, Vol.115 (16), p.2103-2110
Hauptverfasser:	KHAN, Sohail Q, DHILLON, Onkar S, O'BRIEN, Russell J, STRUCK, Joachim, QUINN, Paulene A, MORGENTHALER, Nils G, SQUIRE, Iain B, DAVIES, Joan E, BERGMANN, Andreas, NG, Leong L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Area Under Curve Biological and medical sciences Biomarkers Blood and lymphatic vessels Cardiology. Vascular system Coronary heart disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous England Female Follow-Up Studies Glycopeptides - blood Heart Heart Failure - epidemiology Heart Failure - etiology Humans Kaplan-Meier Estimate Male Medical sciences Middle Aged Myocardial Infarction - blood Myocardial Infarction - complications Myocardial Infarction - diagnostic imaging Myocardial Infarction - mortality Natriuretic Peptide, Brain - blood Neurology Peptide Fragments - blood Prognosis Proportional Hazards Models Prospective Studies Protein Precursors - blood ROC Curve Survival Analysis Treatment Outcome Ultrasonography Vascular diseases and vascular malformations of the nervous system Vasopressins - blood
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Zusammenfassung:	The role of the vasopressin system after acute myocardial infarction is unclear. Copeptin, the C-terminal part of the vasopressin prohormone, is secreted stoichiometrically with vasopressin. We compared the prognostic value of copeptin and an established marker, N-terminal pro-B-type natriuretic peptide (NTproBNP), after acute myocardial infarction. In this prospective single-hospital study, we recruited 980 consecutive post-acute myocardial infarction patients (718 men, median [range] age 66 [24 to 95] years), with follow-up over 342 (range 0 to 764) days. Plasma copeptin was highest on admission (n=132, P
ISSN:	0009-7322 1524-4539
DOI:	10.1161/CIRCULATIONAHA.106.685503