Influence of Cerebrovascular Arteriosclerosis on Cerebral Oxygenation During Exercise

Background Although it is assumed that cerebral oxygenation during exercise is influenced by both cardiopulmonary function and cerebrovascular arteriosclerosis, the latter factor has not been fully clarified. In the present study the relationship between the degree of cerebrovascular arteriosclerosis and cerebral oxygenation during exercise was investigated. Methods and Results A total of 109 patients (69 patients with coronary artery disease, 40 patients with hypertensive heart disease) (61.7±9.7 years) performed a symptom-limited exercise test with respiratory gas measurements (CPX). From the respiratory gas analysis, peak O2 uptake (VO2), the slope of the increase in VO2 to the increase in work rate (ΔVO 2/ΔWR), and the slope of the increase in ventilation to the increase in CO2 output (VE/VCO2 slope) were calculated. Oxyhemoglobin (O2Hb) at the forehead was monitored using near-infrared spectroscopy. The brain ischemic score was counted based upon fluid-attenuated inversion recovery images of magnetic resonance imaging and expressed from 0 to 4. When compared with patients with a lower ischemic score (