Lack of Association between Interleukin-1 Gene Cluster Polymorphisms and Glaucoma in Chinese Subjects

Lack of Association between Interleukin-1 Gene Cluster Polymorphisms and Glaucoma in Chinese Subjects

A recent study identified single nucleotide polymorphisms (SNPs) within the IL-1 gene cluster at chromosomal locus 2q13 that were associated with reduced risk for primary open-angle glaucoma (POAG) in whites. The purpose of this study was to investigate the association between IL-1 SNPs and glaucoma...

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Veröffentlicht in:Investigative ophthalmology & visual science 2007-05, Vol.48 (5), p.2123-2126
Hauptverfasser: How, Alicia C. S, Aung, Tin, Chew, Xinyi, Yong, Victor H. K, Lim, Marcus C. C, Lee, Kelvin Y. C, Toh, Ju-Yuan, Li, Yuqing, Liu, Jianjun, Vithana, Eranga N
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Chromosomes, Human, Pair 2 - genetics
Eye and associated structures. Visual pathways and centers. Vision
Female
Fundamental and applied biological sciences. Psychology
Genotype
Glaucoma and intraocular pressure
Glaucoma, Angle-Closure - genetics
Glaucoma, Open-Angle - genetics
Haplotypes
Humans
Interleukin-1 - genetics
Intraocular Pressure
Male
Medical sciences
Middle Aged
Multigene Family
Ocular Hypertension - genetics
Ophthalmology
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Vertebrates: nervous system and sense organs
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Zusammenfassung:A recent study identified single nucleotide polymorphisms (SNPs) within the IL-1 gene cluster at chromosomal locus 2q13 that were associated with reduced risk for primary open-angle glaucoma (POAG) in whites. The purpose of this study was to investigate the association between IL-1 SNPs and glaucoma in Chinese patients with either POAG or primary-angle closure glaucoma (PACG). Patients with POAG with a mean IOP without treatment that was consistently
ISSN:0146-0404
1552-5783
1552-5783
DOI:10.1167/iovs.06-1213