Palladium‐Catalyzed Intermolecular Ene–Yne Coupling: Development of an Atom‐Efficient Mizoroki–Heck‐Type Reaction

Palladium‐Catalyzed Intermolecular Ene–Yne Coupling: Development of an Atom‐Efficient Mizoroki–Heck‐Type Reaction

Direct and to the point: A palladium(II) catalytic system based on a palladium hydride species provides access to highly substituted 1,3‐dienes through a direct coupling of alkynes with alkenes in a base‐free Mizoroki–Heck‐type reaction with full atom economy (see scheme; R=amide, borate, C(OH)Me2,...

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Veröffentlicht in:Angewandte Chemie International Edition 2008-01, Vol.47 (14), p.2668-2672
Hauptverfasser: Lindhardt (neé Hansen), Anders T., Mantel, Mette Louise H., Skrydstrup, Troels
Format: Artikel
Sprache:eng
Schlagworte:
alkenes
Alkenes - chemistry
alkynes
Catalysis
Hydrogen - chemistry
Mizoroki–Heck reaction
Molecular Structure
palladium
Palladium - chemistry
phosphane ligands
Stereoisomerism
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Beschreibung
Zusammenfassung:Direct and to the point: A palladium(II) catalytic system based on a palladium hydride species provides access to highly substituted 1,3‐dienes through a direct coupling of alkynes with alkenes in a base‐free Mizoroki–Heck‐type reaction with full atom economy (see scheme; R=amide, borate, C(OH)Me2, Oalkyl).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200705558