Recent progress in the development of derivatization reagents having a benzofurazan structure

Chemical derivatization is often used to enhance the detectability of the target compounds and to improve the separation efficiency in high‐performance liquid chromatography (HPLC). In this review, we describe the recent progress in the development of derivatization reagents having a benzofurazan st...

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Veröffentlicht in:	Biomedical chromatography 2008-04, Vol.22 (4), p.343-353
Hauptverfasser:	Santa, Tomofumi, Fukushima, Takeshi, Ichibangase, Tomoko, Imai, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	2,1,3‐benzoxadiazole 3-benzoxadiazole benzofurazan Benzoxazoles - chemistry Chromatography, High Pressure Liquid derivatization reagent fluorescence Fluorescent Dyes - chemistry high-performance liquid chromatography Indicators and Reagents - chemistry mass spectrometry Molecular Structure
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Zusammenfassung:	Chemical derivatization is often used to enhance the detectability of the target compounds and to improve the separation efficiency in high‐performance liquid chromatography (HPLC). In this review, we describe the recent progress in the development of derivatization reagents having a benzofurazan structure, namely, the fluorogenic reagents, water‐soluble reagents, reagents for the analysis of peptides and proteins, and reagents for mass spectrometric detection. The application of these reagents to bio‐samples is also briefly described. Copyright © 2007 John Wiley & Sons, Ltd.
ISSN:	0269-3879 1099-0801
DOI:	10.1002/bmc.945