Enantioselective Organocatalytic Double Michael Addition Reactions

Enantioselective Organocatalytic Double Michael Addition Reactions

A novel organocatalytic, enantioselective domino double Michael addition reaction of α,β-unsaturated aldehydes with ethyl 4-mercapto-2-butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantio...

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Veröffentlicht in:Organic letters 2007-04, Vol.9 (9), p.1833-1835
Hauptverfasser: Li, Hao, Zu, Liansuo, Xie, Hexin, Wang, Jian, Jiang, Wei, Wang, Wei
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel organocatalytic, enantioselective domino double Michael addition reaction of α,β-unsaturated aldehydes with ethyl 4-mercapto-2-butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantioselectivities.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol070581y