A Nanoparticulate Drug-Delivery System for Rivastigmine: Physico-Chemical and in vitro Biological Characterization

The preparation and characterization of surface‐PEGylated polymeric nanoparticles are described. These systems were obtained by UV irradiation of PHM and PHM‐PEG2000 as an inverse microemulsion, using an aqueous solution of the PHM/PHM‐PEG2000 copolymer mixture as the internal phase and triacetin saturated with water as the external phase, and characterized by dimensional analysis, zeta‐potential measurements and XPS. in vitro biological tests demonstrated their cell compatibility and their ability to escape from phagocytosis. Rivastigmine was encapsulated into the nanoparticle structure and drug‐release profiles from loaded samples were investigated in PBS at pH = 7.4 and human plasma.