Interleukin 1 beta gene polymorphism and risk of cervical cancer

Abstract Objective To determine whether a polymorphism at position + 3953 in exon 5 of the lL-1β gene ( IL-1β + 3953), a condition associated with an increased risk for a number of inflammatory diseases, is also involved in the development of cervical cancer. Method We isolated DNA from peripheral blood in 150 women with cervical cancer and 200 healthy controls, and IL-1β + 3953 allele polymorphism was determined by polymerase chain reaction. Results Genotypes A1/A2 and A2/A2 + A1/A2 were associated with increased risk of cervical cancer (odds ratio [OR], 2.88; 95% confidence interval [CI], 1.78–4.67; P < 0.001 and OR, 2.85; 95% CI, 1.77–4.6; P < 0.001, respectively). The risk in a passive smoker with A2/A2 or A1/A2 genotype was increased more than 5-fold (OR, 5.69; 95% CI, 2.61–12.50; P < 0.001) compared with a nonsmoker with the A1/A1 genotype. Conclusion This study provides evidence of an association between lL-1β + 3953 polymorphism and risk of cervical cancer.