Synthesis and bioevaluation of 22-hydroxyacuminatine analogs

A series of 22-hydroxyacuminatine analogs was prepared by using different Friedländer condensations. Several of the new compounds were tested for antiproliferative activity on cancer cell lines and for topoisomerase I inhibitory activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-03, Vol.18 (6), p.2143-2146
Hauptverfasser:	Grillet, François, Baumlová, Barbora, Prévost, Grégoire, Constant, Jean-François, Chaumeron, Sophie, Bigg, Dennis C.H., Greene, Andrew E., Kanazawa, Alice
Format:	Artikel
Sprache:	eng
Schlagworte:	22-Hydroxyacuminatine analogs Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Biological and medical sciences Camptothecin Cytotoxicity DNA Topoisomerases, Type I - genetics General aspects Humans Indolizines - chemical synthesis Indolizines - chemistry Indolizines - pharmacology Medical sciences Molecular Structure Neoplasms - drug therapy Neoplasms - enzymology Pharmacology. Drug treatments Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Structure-Activity Relationship Synthesis Topoisomerase I Topoisomerase I Inhibitors Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	A series of 22-hydroxyacuminatine analogs was prepared by using different Friedländer condensations. Several of the new compounds were tested for antiproliferative activity on cancer cell lines and for topoisomerase I inhibitory activity.
ISSN:	0960-894X 0968-0896 1464-3405 1464-3391
DOI:	10.1016/j.bmcl.2008.01.082