Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: no association in patients from Germany, Hungary and Poland

Polymorphisms in the CTLA4 gene region have been associated with susceptibility to autoimmune diseases. The recently described single nucleotide polymorphism CT60, located in the 3' untranslated region of CTLA4 is associated with Graves' disease, thyroiditis, autoimmune diabetes and other...

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Veröffentlicht in:	Multiple sclerosis 2008-03, Vol.14 (2), p.153-158
Hauptverfasser:	Greve, Bernhard, Simonenko, Rostislav, Illes, Zsolt, Peterfalvi, Agnes, Hamdi, Nada, Mycko, Marcin P, Selmaj, Krzysztof W, Rozsa, Csilla, Rajczy, Katalin, Bauer, Peter, Berger, Klaus, Weissert, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - genetics Antigens, CD - immunology Autoimmunity - genetics Biological and medical sciences CTLA-4 Antigen Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Gene Frequency Genetic Predisposition to Disease Genotype Germany Humans Hungary Medical sciences Multiple Sclerosis - genetics Multiple Sclerosis - immunology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Poland Polymorphism, Genetic
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Zusammenfassung:	Polymorphisms in the CTLA4 gene region have been associated with susceptibility to autoimmune diseases. The recently described single nucleotide polymorphism CT60, located in the 3' untranslated region of CTLA4 is associated with Graves' disease, thyroiditis, autoimmune diabetes and other autoimmune diseases. A case-control association study was conducted in German, Hungarian and Polish multiple sclerosis (MS) patients and regional control individuals for the CTLA4 CT60 and +49A/G polymorphisms. No significant association of these polymorphisms or respective haplotypes with MS was found. No association of CT60 genotypes with T cell expression of ICOS and CTLA-4 after in vitro stimulation was detected. Multiple Sclerosis 2008; 14: 153—158. http://msj.sagepub.com
ISSN:	1352-4585 1477-0970
DOI:	10.1177/1352458507082357