Quilty Indicates Increased Risk for Microvasculopathy and Poor Survival After Heart Transplantation

Quilty Indicates Increased Risk for Microvasculopathy and Poor Survival After Heart Transplantation

Background The impact of Quilty (sub-endocardial infiltration of lymphocytes) on the development of stenotic microvasculopathy and outcome after heart transplantation has not yet been evaluated. Methods Biopsies ( n = 9,713) obtained within the first post-transplant year from 873 patients (722 men,...

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Veröffentlicht in:The Journal of heart and lung transplantation 2008-03, Vol.27 (3), p.289-296
Hauptverfasser: Hiemann, Nicola E., MD, Knosalla, Christoph, MD, PhD, Wellnhofer, Ernst, MD, Lehmkuhl, Hans B., MD, Hetzer, Roland, MD, PhD, Meyer, Rudolf, MD, PhD
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Biopsy
Cardiology. Vascular system
Constriction, Pathologic - pathology
Endocardium - cytology
Endocardium - pathology
Female
Graft Rejection - diagnosis
Graft Rejection - etiology
Graft Rejection - pathology
Heart Transplantation - mortality
Heart Ventricles - pathology
Humans
Kaplan-Meier Estimate
Lymphocytes - pathology
Male
Medical sciences
Middle Aged
Prognosis
Proportional Hazards Models
Regression Analysis
Retrospective Studies
Risk Factors
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Survival Analysis
Tunica Media - pathology
Vascular Diseases - diagnosis
Vascular Diseases - etiology
Vascular Diseases - pathology
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Zusammenfassung:Background The impact of Quilty (sub-endocardial infiltration of lymphocytes) on the development of stenotic microvasculopathy and outcome after heart transplantation has not yet been evaluated. Methods Biopsies ( n = 9,713) obtained within the first post-transplant year from 873 patients (722 men, age 49.3 ± 0.3 years) were evaluated by light microscopy (hematoxylin–eosin) for Quilty and cellular rejection (ISHLT), stenotic microvasculopathy (luminal radius:medial thickness ratio
ISSN:1053-2498
1557-3117
DOI:10.1016/j.healun.2007.11.573