Creatine treatment in muscle disorders: a meta-analysis of randomised controlled trials

MAIN RESULTS In muscular dystrophies, analysis of pooled data of six trials revealed a significant improvement in maximum voluntary contraction (MVC) of about 8.5% with creatine supplementation compared with placebo ( fig 1 ). CONCLUSIONS There is evidence from randomised controlled trials that shor...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2008-04, Vol.79 (4), p.366-367
Hauptverfasser:	Kley, R A, Tarnopolsky, M A, Vorgerd, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biological and medical sciences Child Child, Preschool Confidence intervals Creatine - administration & dosage Dose-Response Relationship, Drug Energy Metabolism - drug effects Female Glycogen Storage Disease Type V - diagnosis Glycogen Storage Disease Type V - drug therapy Glycogen Storage Disease Type V - genetics Hand Strength Humans Immunomodulators Long-Term Care Male Medical sciences Metabolism Middle Aged Muscle Strength - drug effects Muscular Atrophy - diagnosis Muscular Atrophy - drug therapy Muscular Atrophy - genetics Muscular Dystrophies - diagnosis Muscular Dystrophies - drug therapy Muscular Dystrophies - genetics Neurology Neuromuscular Diseases - diagnosis Neuromuscular Diseases - drug therapy Neuromuscular Diseases - genetics Pharmacology. Drug treatments Randomized Controlled Trials as Topic Registries Systematic review Treatment Outcome
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Zusammenfassung:	MAIN RESULTS In muscular dystrophies, analysis of pooled data of six trials revealed a significant improvement in maximum voluntary contraction (MVC) of about 8.5% with creatine supplementation compared with placebo ( fig 1 ). CONCLUSIONS There is evidence from randomised controlled trials that short and medium term creatine treatment improves muscle strength, increases lean body mass and is well tolerated in patients with muscular dystrophies.
ISSN:	0022-3050 1468-330X
DOI:	10.1136/jnnp.2007.127571