Polymorph control: past, present and future
The appearance and disappearance of polymorphs is no longer a mysterious and inexplicable process. Although methods for polymorph control are still imperfect, there is a large armoury of methods that can be used to tackle this important and challenging problem. We survey the methods and their succes...
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Veröffentlicht in: | Drug discovery today 2008-03, Vol.13 (5), p.198-210 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | The appearance and disappearance of polymorphs is no longer a mysterious and inexplicable process. Although methods for polymorph control are still imperfect, there is a large armoury of methods that can be used to tackle this important and challenging problem. We survey the methods and their successes over the last few years.
A single substance can have multiple crystal forms: some useful, some awkward and even some dangerous. We outline recent approaches to the control of polymorphs. |
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ISSN: | 1359-6446 1878-5832 |
DOI: | 10.1016/j.drudis.2007.11.006 |