Polymorph control: past, present and future

The appearance and disappearance of polymorphs is no longer a mysterious and inexplicable process. Although methods for polymorph control are still imperfect, there is a large armoury of methods that can be used to tackle this important and challenging problem. We survey the methods and their succes...

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Veröffentlicht in:Drug discovery today 2008-03, Vol.13 (5), p.198-210
Hauptverfasser: Llinàs, Antonio, Goodman, Jonathan M.
Format: Artikel
Sprache:eng
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Zusammenfassung:The appearance and disappearance of polymorphs is no longer a mysterious and inexplicable process. Although methods for polymorph control are still imperfect, there is a large armoury of methods that can be used to tackle this important and challenging problem. We survey the methods and their successes over the last few years. A single substance can have multiple crystal forms: some useful, some awkward and even some dangerous. We outline recent approaches to the control of polymorphs.
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2007.11.006