Diminished vancomycin and daptomycin susceptibility during prolonged bacteremia with methicillin-resistant Staphylococcus aureus

Abstract An elderly patient with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia was treated sequentially with vancomycin plus rifampin then daptomycin plus gentamicin. The MRSA strain developed diminished susceptibility to vancomycin (MIC increase and tolerance), daptomycin, and genta...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2008-04, Vol.60 (4), p.437-440
Hauptverfasser:	Bennett, Jason W, Murray, Clinton K, Holmes, Robert L, Patterson, Jan E, Jorgensen, James H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged, 80 and over Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacteremia - microbiology Bacterial diseases Bacterial sepsis Bactericidal effect Bacteriology Biological and medical sciences Daptomycin - pharmacology Daptomycin resistance Female Fundamental and applied biological sciences. Psychology Human bacterial diseases Humans Infectious Disease Infectious diseases Internal Medicine Medical sciences Methicillin Resistance Microbial Sensitivity Tests Microbiology Minimum inhibitory concentration Miscellaneous MRSA bacteremia Rifampin - therapeutic use Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - isolation & purification Vancomycin - pharmacology Vancomycin - therapeutic use Vancomycin tolerance
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Zusammenfassung:	Abstract An elderly patient with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia was treated sequentially with vancomycin plus rifampin then daptomycin plus gentamicin. The MRSA strain developed diminished susceptibility to vancomycin (MIC increase and tolerance), daptomycin, and gentamicin, and resistance to rifampin during therapy.
ISSN:	0732-8893 1879-0070
DOI:	10.1016/j.diagmicrobio.2007.11.002