Immunophenotypic, cytogenetic and functional characterization of circulating endothelial cells in myelodysplastic syndromes

Circulating endothelial cells (CECs) are associated with neoangiogenesis in various malignant disorders. Using flow cytometry, we studied CECs in 128 patients with myelodysplastic syndrome (MDS). MDS patients had higher CEC levels than controls ( P

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Veröffentlicht in:	Leukemia 2008-03, Vol.22 (3), p.530-537
Hauptverfasser:	Della Porta, M G, Malcovati, L, Rigolin, G M, Rosti, V, Bonetti, E, Travaglino, E, Boveri, E, Gallì, A, Boggi, S, Ciccone, M, Pramparo, T, Mazzini, G, Invernizzi, R, Lazzarino, M, Cazzola, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Angiogenesis Biological and medical sciences Bone Marrow - blood supply Cancer Research Care and treatment Cell Count Cell Lineage Chromosome Aberrations Clone Cells - pathology Colony-forming cells Colony-Forming Units Assay Critical Care Medicine Cytogenetics Diagnosis Disease Progression Endothelial cells Endothelial Cells - chemistry Endothelial Cells - pathology Epithelial cells Female Flow Cytometry Fluorescence Fluorescence in situ hybridization Genetic aspects Health aspects Hematologic and hematopoietic diseases Hematology Hemopoiesis Humans Hybridization analysis Immunophenotyping In Situ Hybridization, Fluorescence Intensive Internal Medicine Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Medicine Medicine & Public Health Microenvironments Middle Aged Myelodysplastic syndrome Myelodysplastic syndromes Myelodysplastic Syndromes - blood Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - pathology Myelodysplastic Syndromes - physiopathology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - pathology Oncology original-article Polymerase Chain Reaction Progenitor cells Prospective Studies Risk groups Therapeutic applications
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Zusammenfassung:	Circulating endothelial cells (CECs) are associated with neoangiogenesis in various malignant disorders. Using flow cytometry, we studied CECs in 128 patients with myelodysplastic syndrome (MDS). MDS patients had higher CEC levels than controls ( P
ISSN:	0887-6924 1476-5551
DOI:	10.1038/sj.leu.2405069