Long-term results following multidisciplinary treatment of localized Ewing's sarcoma in children and adolescents

To identify results and prognostic factors on long-term survival and local control following treatment of localized Ewing's sarcoma. Between 1979 and 2004, a total of 60 children and young adults with Ewing's sarcoma were treated. Patients with distant metastases at presentation (n = 6) and recurrent cases (n = 2) were excluded from this analysis. Patients were exclusively treated within ongoing national and international protocols CESS-81, CESS-86, EICESS-92, EURO-EWING-99. All patients received local irradiation with a total dose of 45-60 Gy; in addition, 41 (79%) of the patients had local surgical procedures, 27 (52%) of them with clear margins. Overall survival rates at 5 and 10 years were 56% and 45%, respectively. Patients