Atovaquone-Statine "Double-Drugs" with High Antiplasmodial Activity

Combining chemicals. Malaria is one of the most widespread parasitic infections in the world, however, the unavailability of a vaccine and the spread and intensification of drug resistance over the past 15–20 years have led to a dramatic decline in the efficacy of the most affordable antimalarial dr...

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Veröffentlicht in:ChemMedChem 2008-03, Vol.3 (3), p.418-420
Hauptverfasser: Romeo, Sergio, Parapini, Silvia, Dell'Agli, Mario, Vaiana, Nadia, Magrone, Pietro, Galli, Germana, Sparatore, Anna, Taramelli, Donatella, Bosisio, Enrica
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Sprache:eng
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Zusammenfassung:Combining chemicals. Malaria is one of the most widespread parasitic infections in the world, however, the unavailability of a vaccine and the spread and intensification of drug resistance over the past 15–20 years have led to a dramatic decline in the efficacy of the most affordable antimalarial drugs. Herein, the development of “double‐drugs” to tackle inhibition of P. falciparum growth is discussed.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.200700166