Essential Role of Endothelial Nitric Oxide Synthase in Vascular Effects of Erythropoietin

Erythropoietin (EPO) fosters tissue oxygenation by stimulating erythropoiesis. More recently, EPO has been recognized as a tissue-protective cytokine. In this study, we tested the hypothesis that endothelial NO synthase (eNOS) plays a key role in the vascular protective effect of EPO. A murine model...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2007-05, Vol.49 (5), p.1142-1148
Hauptverfasser:	d’Uscio, Livius V, Smith, Leslie A, Santhanam, Anantha V, Richardson, Darcy, Nath, Karl A, Katusic, Zvonimir S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Antihypertensive agents Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Cardiovascular system Carotid Artery Injuries - enzymology Carotid Artery Injuries - pathology Carotid Artery Injuries - physiopathology Carotid Artery, Common - drug effects Carotid Artery, Common - enzymology Carotid Artery, Common - physiopathology Clinical manifestations. Epidemiology. Investigative techniques. Etiology Cytoprotection Endothelium, Vascular - physiopathology Erythropoietin - pharmacology Humans Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Nitric Oxide Synthase Type III - deficiency Nitric Oxide Synthase Type III - metabolism Pharmacology. Drug treatments Recombinant Proteins Vasodilation Vasodilator Agents - pharmacology Wound Healing - drug effects
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Zusammenfassung:	Erythropoietin (EPO) fosters tissue oxygenation by stimulating erythropoiesis. More recently, EPO has been recognized as a tissue-protective cytokine. In this study, we tested the hypothesis that endothelial NO synthase (eNOS) plays a key role in the vascular protective effect of EPO. A murine model of wire-induced injury of carotid artery was used to examine the effect of EPO on endothelial repair and arterial wall architecture. Recombinant human EPO (1000 U/kg, SC, biweekly) was administered for 2 weeks in wild-type and eNOS-deficient mice after which reactivity of isolated carotid arteries was studied in vitro, and the vasculature was histologically assessed. Injured arteries exhibited impairment of endothelium-dependent relaxations to acetylcholine (P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/HYPERTENSIONAHA.106.085704