Endogenous Endothelin in Human Coronary Vascular Function: Differential Contribution of Endothelin Receptor Types A and B

Endothelin 1 mediates coronary vasoconstriction and endothelial dysfunction via endothelin receptor type A (ETA) activation. However, the effects of selective endothelin receptor type B (ETB) and combined ETA+B receptor blockade on coronary vasomotion are unknown. We measured coronary vascular tone...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2007-05, Vol.49 (5), p.1134-1141
Hauptverfasser:	Halcox, Julian P.J, Nour, Khaled R.A, Zalos, Gloria, Quyyumi, Arshed A
Format:	Artikel
Sprache:	eng
Schlagworte:	Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Coronary Artery Disease - metabolism Coronary Artery Disease - physiopathology Coronary Circulation - drug effects Coronary Vessels - drug effects Coronary Vessels - physiopathology Drug Combinations Endothelin A Receptor Antagonists Endothelin B Receptor Antagonists Endothelin-1 - blood Endothelin-1 - metabolism Endothelium, Vascular - physiopathology Fundamental and applied biological sciences. Psychology Humans Medical sciences Microcirculation - drug effects Nitrogen Oxides - blood Oligopeptides - pharmacology Peptides, Cyclic - pharmacology Pericardium Piperidines - pharmacology Receptor, Endothelin A - metabolism Receptor, Endothelin B - metabolism Vasoconstriction Vasodilation Vasomotor System - drug effects Vertebrates: cardiovascular system
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Zusammenfassung:	Endothelin 1 mediates coronary vasoconstriction and endothelial dysfunction via endothelin receptor type A (ETA) activation. However, the effects of selective endothelin receptor type B (ETB) and combined ETA+B receptor blockade on coronary vasomotion are unknown. We measured coronary vascular tone and endothelium-dependent and -independent vasomotor function before and after selective infusion of BQ-788 (an ETB receptor antagonist) or combined infusion of BQ-788+BQ-123 (an ETA antagonist) into unobstructed coronary arteries of 39 patients with coronary atherosclerosis or risk factors undergoing cardiac catheterization. BQ-788 did not affect epicardial diameter but constricted the microcirculation (P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/HYPERTENSIONAHA.106.083303