Early Exercise Training Normalizes Myofilament Function and Attenuates Left Ventricular Pump Dysfunction in Mice With a Large Myocardial Infarction

The extent and mechanism of the cardiac benefit of early exercise training following myocardial infarction (MI) is incompletely understood, but may involve blunting of abnormalities in Ca-handling and myofilament function. Consequently, we investigated the effects of 8-weeks of voluntary exercise, s...

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Veröffentlicht in:	Circulation research 2007-04, Vol.100 (7), p.1079-1088
Hauptverfasser:	de Waard, Monique C, van der Velden, Jolanda, Bito, Virginie, Ozdemir, Semir, Biesmans, Liesbeth, Boontje, Nicky M, Dekkers, Dick H.W, Schoonderwoerd, Kees, Schuurbiers, Hans C.H, de Crom, Rini, Stienen, Ger J.M, Sipido, Karin R, Lamers, Jos M.J, Duncker, Dirk J
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Animals Biological and medical sciences Blotting, Western Cardiology. Vascular system Coronary heart disease Cyclic AMP - metabolism Female Fundamental and applied biological sciences. Psychology Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Male Medical sciences Mice Mice, Inbred C57BL Myocardial Contraction Myocardial Infarction - mortality Myocardial Infarction - physiopathology Myocytes, Cardiac - metabolism Permeability Phosphorylation Physical Conditioning, Animal Proteins - metabolism Severity of Illness Index Time Factors Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left Ventricular Remodeling Vertebrates: cardiovascular system
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Zusammenfassung:	The extent and mechanism of the cardiac benefit of early exercise training following myocardial infarction (MI) is incompletely understood, but may involve blunting of abnormalities in Ca-handling and myofilament function. Consequently, we investigated the effects of 8-weeks of voluntary exercise, started early after a large MI, on left ventricular (LV) remodeling and dysfunction in the mouse. Exercise had no effect on survival, MI size or LV dimensions, but improved LV fractional shortening from 8±1 to 12±1%, and LVdP/dtP30 from 5295±207 to 5794±207 mm Hg/s (both P
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.RES.0000262655.16373.37