Enalapril/amlodipine combination in cyclosporine-treated renal transplant recipients: a prospective randomized trial

:  Background:  Most hypertensive renal transplant recipients require two or more antihypertensive medications to achieve blood pressure control. However, which medications must be combined is still a matter of debate. Methods:  A prospective randomized open‐label blinded evaluation trial comparing...

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Veröffentlicht in:Clinical transplantation 2007-03, Vol.21 (2), p.277-284
Hauptverfasser: Halimi, Jean-Michel, Giraudeau, Bruno, Buchler, Matthias, Al-Najjar, Azmi, Etienne, Isabelle, Laouad, Inass, Bruyère, Franck, Lebranchu, Yvon
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Sprache:eng
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Zusammenfassung::  Background:  Most hypertensive renal transplant recipients require two or more antihypertensive medications to achieve blood pressure control. However, which medications must be combined is still a matter of debate. Methods:  A prospective randomized open‐label blinded evaluation trial comparing the six‐month effects of the amlodipine–enalapril combination (n = 32) vs. enalapril alone (n = 33) and vs. amlodipine alone (n = 34) on arterial pressure, renal function, albuminuria and tolerability. Results:  At six months, diastolic arterial pressure was more adequately controlled (i.e.,
ISSN:0902-0063
1399-0012
DOI:10.1111/j.1399-0012.2007.00643.x