Comparison of intravascular ultrasound and quantitative coronary angiography for the assessment of coronary artery disease progression

The relative merits of quantitative coronary analysis (QCA) and intravascular ultrasound (IVUS) for the assessment of progression/regression in coronary artery disease are uncertain. To explore this subject further, we analyzed the angiographic and IVUS data derived from a contemporary clinical tria...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2007-04, Vol.115 (14), p.1851-1857
Hauptverfasser:	BERRY, Colin, L'ALLIER, Philippe L, GREGOIRE, Jean, LESPERANCE, Jacques, LEVESQUE, Sylvie, IBRAHIM, Reda, TARDIF, Jean-Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - therapeutic use Aged Atherosclerosis - diagnostic imaging Atherosclerosis - pathology Biological and medical sciences Biomarkers Blood and lymphatic vessels Cardiology. Vascular system Cineangiography Coronary Angiography - statistics & numerical data Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - drug therapy Coronary Artery Disease - physiopathology Coronary Artery Disease - urine Coronary heart disease Disease Progression Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Drug Therapy, Combination Dyslipidemias - drug therapy Endothelium, Vascular - physiopathology Female Heart Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Image Processing, Computer-Assisted Male Medical sciences Middle Aged Multicenter Studies as Topic Myocardial Infarction - etiology Myocardial Infarction - prevention & control Randomized Controlled Trials as Topic - statistics & numerical data Sterol O-Acyltransferase - antagonists & inhibitors Sulfonic Acids - therapeutic use Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Ultrasonography, Interventional - statistics & numerical data
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Zusammenfassung:	The relative merits of quantitative coronary analysis (QCA) and intravascular ultrasound (IVUS) for the assessment of progression/regression in coronary artery disease are uncertain. To explore this subject further, we analyzed the angiographic and IVUS data derived from a contemporary clinical trial population. We investigated the relationships between QCA and IVUS at single time points (n=525) and also for the changes over time (n=432). QCA and IVUS data underwent central laboratory analyses. Statistically significant correlations were observed between the QCA coronary artery score and the IVUS-derived lumen volume (r=0.65, P
ISSN:	0009-7322 1524-4539
DOI:	10.1161/CIRCULATIONAHA.106.655654