Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338
Saccharopolyspora erythraea is used for the industrial-scale production of the antibiotic erythromycin A, derivatives of which play a vital role in medicine. The sequenced chromosome of this soil bacterium comprises 8,212,805 base pairs, predicted to encode 7,264 genes. It is circular, like those of...
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Veröffentlicht in: | Nature biotechnology 2007-04, Vol.25 (4), p.447-453 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Saccharopolyspora erythraea
is used for the industrial-scale production of the antibiotic erythromycin A, derivatives of which play a vital role in medicine. The sequenced chromosome of this soil bacterium comprises 8,212,805 base pairs, predicted to encode 7,264 genes. It is circular, like those of the pathogenic actinomycetes
Mycobacterium tuberculosis
and
Corynebacterium diphtheriae
, but unlike the linear chromosomes of the model actinomycete
Streptomyces coelicolor A3(2)
and the closely related
Streptomyces avermitilis
. The
S. erythraea
genome contains at least 25 gene clusters for production of known or predicted secondary metabolites, at least 72 genes predicted to confer resistance to a range of common antibiotic classes and many sets of duplicated genes to support its saprophytic lifestyle. The availability of the genome sequence of
S. erythraea
will improve insight into its biology and facilitate rational development of strains to generate high-titer producers of clinically important antibiotics. |
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ISSN: | 1087-0156 1546-1696 |
DOI: | 10.1038/nbt1297 |