A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization
: This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated...
Gespeichert in:
| Veröffentlicht in: | The breast journal 2008-03, Vol.14 (2), p.153-157 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 157 |
|---|---|
| container_issue | 2 |
| container_start_page | 153 |
| container_title | The breast journal |
| container_volume | 14 |
| creator | Hughes, Jenevieve H. Mason, Mark C. Gray, Richard J. McLaughlin, Sarah A. Degnim, Amy C. Fulmer, Jack T. Pockaj, Barbara A. Karstaedt, Patricia J. Roarke, Michael C. |
| description | : This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated with RSL. Margins were considered “negative” if ≥2 mm from in‐situ and invasive disease. Pain and convenience scores were recorded on a 10‐point scale. Patient characteristics and histology were similar. The lesion and localization device were retrieved in all patients. Margins of the first specimen were negative in 73% of RSL patients, versus 54% of WL patients (p |
| doi_str_mv | 10.1111/j.1524-4741.2007.00546.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70368327</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70368327</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4046-2f2ff9ca09859bef59b7b42277cca73ff0296aa7f85e78d618d2fce1607c6683</originalsourceid><addsrcrecordid>eNqNkE1P4zAQhi3Eiu-_gHzilmA7ju1IXAraBVbla1st3CzXGUsuaQN2ulv49bikAnHDB3skP-_M6EEIU5LTdI6nOS0Zz7jkNGeEyJyQkot8uYF2Pj42U01kmVHGHrbRboxTQgirCN9C21QxrkrBdhAM8NWi6XwWfQf4r2l8bTrfzvE4eNPg1uE_pvatsZ3_B3gEUONhaxP22mMmYjPHg6aDMDfvTNfiex_gC7aPfjjTRDhYv3to_Ovn-OwiG96cX54NhpnlhIuMOeZcZQ2pVFlNwKVLTjhjUlprZOFc2l8YI50qQapaUFUzZ4EKIq0QqthDR33bp9A-LyB2euajhaYxc2gXUUtSJIrJBKoetKGNMYDTT8HPTHjRlOiVYT3VK5F6JVKvDOt3w3qZoofrGYvJDOrP4FppAk564L9v4OXbjfX49HcqUjzr4z52sPyIm_CohSxkqe-vz_Xd7YhVV2qkq-INaOuZYg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70368327</pqid></control><display><type>article</type><title>A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Hughes, Jenevieve H. ; Mason, Mark C. ; Gray, Richard J. ; McLaughlin, Sarah A. ; Degnim, Amy C. ; Fulmer, Jack T. ; Pockaj, Barbara A. ; Karstaedt, Patricia J. ; Roarke, Michael C.</creator><creatorcontrib>Hughes, Jenevieve H. ; Mason, Mark C. ; Gray, Richard J. ; McLaughlin, Sarah A. ; Degnim, Amy C. ; Fulmer, Jack T. ; Pockaj, Barbara A. ; Karstaedt, Patricia J. ; Roarke, Michael C.</creatorcontrib><description>: This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated with RSL. Margins were considered “negative” if ≥2 mm from in‐situ and invasive disease. Pain and convenience scores were recorded on a 10‐point scale. Patient characteristics and histology were similar. The lesion and localization device were retrieved in all patients. Margins of the first specimen were negative in 73% of RSL patients, versus 54% of WL patients (p < 0.001). A second operation was required in 8% of RSL patients to achieve negative margins, versus 25% of WL patients (p < 0.001). Pain scores were not statistically different. However, the RSL group had higher convenience scores (p = 0.015). RSL is safe, effective, and compared to WL, reduces the rates of intraoperative re‐excision and reoperation for positive margins by 68%. Patient satisfaction is improved with RSL. We strongly favor RSL over WL.</description><identifier>ISSN: 1075-122X</identifier><identifier>EISSN: 1524-4741</identifier><identifier>DOI: 10.1111/j.1524-4741.2007.00546.x</identifier><identifier>PMID: 18248562</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biopsy - methods ; Breast - pathology ; breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - surgery ; Female ; Humans ; Iodine Radioisotopes ; Mammography ; Mastectomy, Segmental - methods ; Middle Aged ; nonpalpable ; radioactive seed localization ; Radionuclide Imaging ; Reoperation ; wire localization</subject><ispartof>The breast journal, 2008-03, Vol.14 (2), p.153-157</ispartof><rights>2008 Blackwell Publishing, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4046-2f2ff9ca09859bef59b7b42277cca73ff0296aa7f85e78d618d2fce1607c6683</citedby><cites>FETCH-LOGICAL-c4046-2f2ff9ca09859bef59b7b42277cca73ff0296aa7f85e78d618d2fce1607c6683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1524-4741.2007.00546.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1524-4741.2007.00546.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18248562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hughes, Jenevieve H.</creatorcontrib><creatorcontrib>Mason, Mark C.</creatorcontrib><creatorcontrib>Gray, Richard J.</creatorcontrib><creatorcontrib>McLaughlin, Sarah A.</creatorcontrib><creatorcontrib>Degnim, Amy C.</creatorcontrib><creatorcontrib>Fulmer, Jack T.</creatorcontrib><creatorcontrib>Pockaj, Barbara A.</creatorcontrib><creatorcontrib>Karstaedt, Patricia J.</creatorcontrib><creatorcontrib>Roarke, Michael C.</creatorcontrib><title>A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization</title><title>The breast journal</title><addtitle>Breast J</addtitle><description>: This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated with RSL. Margins were considered “negative” if ≥2 mm from in‐situ and invasive disease. Pain and convenience scores were recorded on a 10‐point scale. Patient characteristics and histology were similar. The lesion and localization device were retrieved in all patients. Margins of the first specimen were negative in 73% of RSL patients, versus 54% of WL patients (p < 0.001). A second operation was required in 8% of RSL patients to achieve negative margins, versus 25% of WL patients (p < 0.001). Pain scores were not statistically different. However, the RSL group had higher convenience scores (p = 0.015). RSL is safe, effective, and compared to WL, reduces the rates of intraoperative re‐excision and reoperation for positive margins by 68%. Patient satisfaction is improved with RSL. We strongly favor RSL over WL.</description><subject>Biopsy - methods</subject><subject>Breast - pathology</subject><subject>breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Iodine Radioisotopes</subject><subject>Mammography</subject><subject>Mastectomy, Segmental - methods</subject><subject>Middle Aged</subject><subject>nonpalpable</subject><subject>radioactive seed localization</subject><subject>Radionuclide Imaging</subject><subject>Reoperation</subject><subject>wire localization</subject><issn>1075-122X</issn><issn>1524-4741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P4zAQhi3Eiu-_gHzilmA7ju1IXAraBVbla1st3CzXGUsuaQN2ulv49bikAnHDB3skP-_M6EEIU5LTdI6nOS0Zz7jkNGeEyJyQkot8uYF2Pj42U01kmVHGHrbRboxTQgirCN9C21QxrkrBdhAM8NWi6XwWfQf4r2l8bTrfzvE4eNPg1uE_pvatsZ3_B3gEUONhaxP22mMmYjPHg6aDMDfvTNfiex_gC7aPfjjTRDhYv3to_Ovn-OwiG96cX54NhpnlhIuMOeZcZQ2pVFlNwKVLTjhjUlprZOFc2l8YI50qQapaUFUzZ4EKIq0QqthDR33bp9A-LyB2euajhaYxc2gXUUtSJIrJBKoetKGNMYDTT8HPTHjRlOiVYT3VK5F6JVKvDOt3w3qZoofrGYvJDOrP4FppAk564L9v4OXbjfX49HcqUjzr4z52sPyIm_CohSxkqe-vz_Xd7YhVV2qkq-INaOuZYg</recordid><startdate>200803</startdate><enddate>200803</enddate><creator>Hughes, Jenevieve H.</creator><creator>Mason, Mark C.</creator><creator>Gray, Richard J.</creator><creator>McLaughlin, Sarah A.</creator><creator>Degnim, Amy C.</creator><creator>Fulmer, Jack T.</creator><creator>Pockaj, Barbara A.</creator><creator>Karstaedt, Patricia J.</creator><creator>Roarke, Michael C.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200803</creationdate><title>A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization</title><author>Hughes, Jenevieve H. ; Mason, Mark C. ; Gray, Richard J. ; McLaughlin, Sarah A. ; Degnim, Amy C. ; Fulmer, Jack T. ; Pockaj, Barbara A. ; Karstaedt, Patricia J. ; Roarke, Michael C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4046-2f2ff9ca09859bef59b7b42277cca73ff0296aa7f85e78d618d2fce1607c6683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biopsy - methods</topic><topic>Breast - pathology</topic><topic>breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Iodine Radioisotopes</topic><topic>Mammography</topic><topic>Mastectomy, Segmental - methods</topic><topic>Middle Aged</topic><topic>nonpalpable</topic><topic>radioactive seed localization</topic><topic>Radionuclide Imaging</topic><topic>Reoperation</topic><topic>wire localization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hughes, Jenevieve H.</creatorcontrib><creatorcontrib>Mason, Mark C.</creatorcontrib><creatorcontrib>Gray, Richard J.</creatorcontrib><creatorcontrib>McLaughlin, Sarah A.</creatorcontrib><creatorcontrib>Degnim, Amy C.</creatorcontrib><creatorcontrib>Fulmer, Jack T.</creatorcontrib><creatorcontrib>Pockaj, Barbara A.</creatorcontrib><creatorcontrib>Karstaedt, Patricia J.</creatorcontrib><creatorcontrib>Roarke, Michael C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The breast journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hughes, Jenevieve H.</au><au>Mason, Mark C.</au><au>Gray, Richard J.</au><au>McLaughlin, Sarah A.</au><au>Degnim, Amy C.</au><au>Fulmer, Jack T.</au><au>Pockaj, Barbara A.</au><au>Karstaedt, Patricia J.</au><au>Roarke, Michael C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization</atitle><jtitle>The breast journal</jtitle><addtitle>Breast J</addtitle><date>2008-03</date><risdate>2008</risdate><volume>14</volume><issue>2</issue><spage>153</spage><epage>157</epage><pages>153-157</pages><issn>1075-122X</issn><eissn>1524-4741</eissn><abstract>: This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated with RSL. Margins were considered “negative” if ≥2 mm from in‐situ and invasive disease. Pain and convenience scores were recorded on a 10‐point scale. Patient characteristics and histology were similar. The lesion and localization device were retrieved in all patients. Margins of the first specimen were negative in 73% of RSL patients, versus 54% of WL patients (p < 0.001). A second operation was required in 8% of RSL patients to achieve negative margins, versus 25% of WL patients (p < 0.001). Pain scores were not statistically different. However, the RSL group had higher convenience scores (p = 0.015). RSL is safe, effective, and compared to WL, reduces the rates of intraoperative re‐excision and reoperation for positive margins by 68%. Patient satisfaction is improved with RSL. We strongly favor RSL over WL.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18248562</pmid><doi>10.1111/j.1524-4741.2007.00546.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1075-122X |
| ispartof | The breast journal, 2008-03, Vol.14 (2), p.153-157 |
| issn | 1075-122X 1524-4741 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70368327 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biopsy - methods Breast - pathology breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - diagnostic imaging Breast Neoplasms - surgery Female Humans Iodine Radioisotopes Mammography Mastectomy, Segmental - methods Middle Aged nonpalpable radioactive seed localization Radionuclide Imaging Reoperation wire localization |
| title | A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T23%3A41%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Multi-site%20Validation%20Trial%20of%20Radioactive%20Seed%20Localization%20as%20an%20Alternative%20to%20Wire%20Localization&rft.jtitle=The%20breast%20journal&rft.au=Hughes,%20Jenevieve%20H.&rft.date=2008-03&rft.volume=14&rft.issue=2&rft.spage=153&rft.epage=157&rft.pages=153-157&rft.issn=1075-122X&rft.eissn=1524-4741&rft_id=info:doi/10.1111/j.1524-4741.2007.00546.x&rft_dat=%3Cproquest_cross%3E70368327%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70368327&rft_id=info:pmid/18248562&rfr_iscdi=true |