A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization

: This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated...

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Veröffentlicht in:	The breast journal 2008-03, Vol.14 (2), p.153-157
Hauptverfasser:	Hughes, Jenevieve H., Mason, Mark C., Gray, Richard J., McLaughlin, Sarah A., Degnim, Amy C., Fulmer, Jack T., Pockaj, Barbara A., Karstaedt, Patricia J., Roarke, Michael C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy - methods Breast - pathology breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - diagnostic imaging Breast Neoplasms - surgery Female Humans Iodine Radioisotopes Mammography Mastectomy, Segmental - methods Middle Aged nonpalpable radioactive seed localization Radionuclide Imaging Reoperation wire localization
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Beschreibung
Zusammenfassung:	: This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated with RSL. Margins were considered “negative” if ≥2 mm from in‐situ and invasive disease. Pain and convenience scores were recorded on a 10‐point scale. Patient characteristics and histology were similar. The lesion and localization device were retrieved in all patients. Margins of the first specimen were negative in 73% of RSL patients, versus 54% of WL patients (p
ISSN:	1075-122X 1524-4741
DOI:	10.1111/j.1524-4741.2007.00546.x